Household C G-protein-coupled receptors (GPCRs) function as obligate dimers with extracellular domains that identify little ligands, bringing about G-protein activation on the transmembrane (TM) domains of such receptors by an not known mechanism one . Here we exhibit constructions of homodimers of your household C metabotropic glutamate receptor two (mGlu2) in distinctive practical states and in advanced with heterotrimeric G i . Upon activation of your extracellular domain, The 2 transmembrane domains bear extensive rearrangement in relative orientation to establish an asymmetric TM6-TM6 interface that encourages conformational variations within the cytoplasmic area of 1 protomer.

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